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Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion 期刊论文 WOS高被引论文 WOS热点论文

编号：

1630AF2B93DD0E7AC49B0FD7ED6C1201
作者：

Tao, Chunrong G.(陶春蓉)#^[1,2]Nogueira, Raul^[27]Zhu, Yuyou(朱余友)^[1,2]Sun, Jun^[1,2];Han, Hongxing^[3];Yuan, Guangxiong(袁光雄)^[4]Wen, Changming^[5];Zhou, Peiyang(周佩洋)^[6]Chen, Wenhuo(陈文伙)^[7]Zeng, Guoyong^[8];Li, Yuwen^[9];Ma, Zhengfei^[10];Yu, Chuanqing^[13];Su, Junfeng^[14];Zhou, Zhiming(周志明)^[15]Chen, Zhongjun^[16];Liao, Geng^[17];Sun, Yaxuan^[18];Ren, Youquan^[19];Zhang, Hui^[20];Chen, Jie^[21];Yue, Xincan^[22];Xiao, Guodong(肖国栋)^[11,12]Wang, Li^[1,2,23];Liu, Rui(刘锐)^[24]Liu, Wenhua(刘文华)^[25]Liu, Yong^[26];Zhang, Chao^[1,2];Liu, Tianlong^[1,2];Song, Jianlong^[1,2];Li, Rui^[1,2];Xu, Pengfei^[1,2]Yin, Yamei^[1,2];Wang, Guoping^[1,2];Baxter, Blaise^[28];Qureshi, Adnan I.^[29,30]Liu, Xinfeng(刘新峰)^[1,2,24]Hu, Wei(胡伟)*^[1,2,31,32]ATTENTION Investigators;
语种：

英文
期刊：

NEW ENGLAND JOURNAL OF MEDICINE ISSN：0028-4793 2022 年 387 卷 15 期 (1361 - 1372) ; OCT 13
收录：
摘要：

Background Data from trials investigating the effects and risks of endovascular thrombectomy for the treatment of stroke due to basilar-artery occlusion are limited. Methods We conducted a multicenter, prospective, randomized, controlled trial of endovascular thrombectomy for basilar-artery occlusion at 36 centers in China. Patients were assigned, in a 2:1 ratio, within 12 hours after the estimated time of basilar-artery occlusion to receive endovascular thrombectomy or best medical care (control). The primary outcome was good functional status, defined as a score of 0 to 3 on the modified Rankin scale (range, 0 [no symptoms] to 6 [death]), at 90 days. Secondary outcomes included a modified Rankin scale score of 0 to 2, distribution across the modified Rankin scale score categories, and quality of life. Safety outcomes included symptomatic intracranial hemorrhage at 24 to 72 hours, 90-day mortality, and procedural complications. Results Of the 507 patients who underwent screening, 340 were in the intention-to-treat population, with 226 assigned to the thrombectomy group and 114 to the control group. Intravenous thrombolysis was used in 31% of the patients in the thrombectomy group and in 34% of those in the control group. Good functional status at 90 days occurred in 104 patients (46%) in the thrombectomy group and in 26 (23%) in the control group (adjusted rate ratio, 2.06; 95% confidence interval [CI], 1.46 to 2.91, P < 0.001). Symptomatic intracranial hemorrhage occurred in 12 patients (5%) in the thrombectomy group and in none in the control group. Results for the secondary clinical and imaging outcomes were generally in the same direction as those for the primary outcome. Mortality at 90 days was 37% in the thrombectomy group and 55% in the control group (adjusted risk ratio, 0.66; 95% CI, 0.52 to 0.82). Procedural complications occurred in 14% of the patients in the thrombectomy group, including one death due to arterial perforation. Conclusions In a trial involving Chinese patients with basilar-artery occlusion, approximately one third of whom received intravenous thrombolysis, endovascular thrombectomy within 12 hours after stroke onset led to better functional outcomes at 90 days than best medical care but was associated with procedural complications and intracerebral hemorrhage.
推荐引用方式
GB/T 7714：

Tao Chunrong G.,Nogueira Raul,Zhu Yuyou, et al. Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion [J].NEW ENGLAND JOURNAL OF MEDICINE,2022,387(15):1361-1372.
APA：

Tao Chunrong G.,Nogueira Raul,Zhu Yuyou,Sun Jun,&ATTENTION Investigators.(2022).Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion .NEW ENGLAND JOURNAL OF MEDICINE,387(15):1361-1372.
MLA：

Tao Chunrong G., et al. "Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion" .NEW ENGLAND JOURNAL OF MEDICINE 387,15(2022):1361-1372.
入库时间：

12/31/2022 10:41:46 PM
更新时间：

12/31/2022 10:41:46 PM

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