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Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct 期刊论文 WOS高被引论文 WOS热点论文

编号：

5CDC143511897A622AE48EC9C3A0F8F9
作者：

Huo, Xiaochuan(霍晓川)#^[1,5]Ma, Gaoting(马高亭)#^[1,5]Tong, Xu^[1,5];Zhang, Xuelei^[1,4,5];Pan, Yuesong(潘岳松)^[1,5]Nguyen, Thanh N. N.^[29];Yuan, Guangxiong(袁光雄)^[6]Han, Hongxing^[8];Chen, Wenhuo(陈文伙)^[11]Wei, Ming^[12];Zhang, Jiangang^[13];Zhou, Zhiming(周志明)^[16]Yao, Xiaoxi^[7];Wang, Guoqing^[9];Song, Weigen^[17];Cai, Xueli(蔡学礼)^[18]Nan, Guangxian(南光贤)Li, Di;Wang, A. YiChou;Ling, Wentong^[19];Cai, Chuwei^[21];Wen, Changming^[14];Wang, En;Zhang, Liyong(张利勇)^[10]Jiang, Changchun^[24];Liu, Yajie^[22];Liao, Geng^[23];Chen, Xiaohui(陈晓辉)^[20]Li, Tianxiao(李天晓)^[15]Liu, Shudong(刘曙东)^[25]Li, Jinglun(李经伦)^[26]Gao, Feng(高峰)^[1,5]Ma, Ning(马宁)^[1,5]Mo, Dapeng(莫大鹏)^[1,5]Song, Ligang(宋立刚)^[1,5]Sun, Xuan(孙萱)^[1,5]Li, Xiaoqing^[1,5];Deng, Yiming(邓一鸣)^[1,5]Luo, Gang(罗岗)^[1,5]Lv, Ming^[2];He, Hongwei(贺红卫)^[2]Liu, Aihua(刘爱华)^[2]Zhang, Jingbo(张静波)^[2]Mu, Shiqing^[2];Liu, Lian(刘恋)^[2]Jing, Jing(荆京)^[3,5]Nie, Ximing^[3,5];Ding, Zeyu^[3,5];Du, Wanliang(杜万良)^[3,5]Zhao, Xingquan(赵性泉)^[3,5]Yang, Pengfei(杨鹏飞)^[27]Liu, Liping(刘丽萍)^[3,5]Wang, Yilong(王伊龙)^[3,5]Liebeskind, David S. S.^[30];Pereira, Vitor M.^[31]Ren, Zeguang(任泽光)#*^[28,32]Wang, Yongjun(王拥军)#*^[5,33]Miao, Zhongrong(缪中荣)#*^[1,5,34]ANGELASPECT Investigators*
语种：

英文
期刊：

NEW ENGLAND JOURNAL OF MEDICINE ISSN：0028-4793 2023 年 388 卷 14 期 (1272 - 1283) ; APR 6
Associated data：

ClinicalTrials.gov/NCT04551664
收录：
摘要：

BackgroundThe role of endovascular therapy for acute stroke with a large infarction has not been extensively studied in differing populations. MethodsWe conducted a multicenter, prospective, open-label, randomized trial in China involving patients with acute large-vessel occlusion in the anterior circulation and an Alberta Stroke Program Early Computed Tomography Score of 3 to 5 (range, 0 to 10, with lower values indicating larger infarction) or an infarct-core volume of 70 to 100 ml. Patients were randomly assigned in a 1:1 ratio within 24 hours from the time they were last known to be well to undergo endovascular therapy and receive medical management or to receive medical management alone. The primary outcome was the score on the modified Rankin scale at 90 days (scores range from 0 to 6, with higher scores indicating greater disability), and the primary objective was to determine whether a shift in the distribution of the scores on the modified Rankin scale at 90 days had occurred between the two groups. Secondary outcomes included scores of 0 to 2 and 0 to 3 on the modified Rankin scale. The primary safety outcome was symptomatic intracranial hemorrhage within 48 hours after randomization. ResultsA total of 456 patients were enrolled; 231 were assigned to the endovascular-therapy group and 225 to the medical-management group. Approximately 28% of the patients in both groups received intravenous thrombolysis. The trial was stopped early owing to the efficacy of endovascular therapy after the second interim analysis. At 90 days, a shift in the distribution of scores on the modified Rankin scale toward better outcomes was observed in favor of endovascular therapy over medical management alone (generalized odds ratio, 1.37; 95% confidence interval, 1.11 to 1.69; P=0.004). Symptomatic intracranial hemorrhage occurred in 14 of 230 patients (6.1%) in the endovascular-therapy group and in 6 of 225 patients (2.7%) in the medical-management group; any intracranial hemorrhage occurred in 113 (49.1%) and 39 (17.3%), respectively. Results for the secondary outcomes generally supported those of the primary analysis. ConclusionsIn a trial conducted in China, patients with large cerebral infarctions had better outcomes with endovascular therapy administered within 24 hours than with medical management alone but had more intracranial hemorrhages. (Funded by Covidien Healthcare International Trading [Shanghai] and others; ANGEL-ASPECT ClinicalTrials.gov number, NCT04551664.)
推荐引用方式
GB/T 7714：

Huo Xiaochuan,Ma Gaoting,Tong Xu, et al. Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct [J].NEW ENGLAND JOURNAL OF MEDICINE,2023,388(14):1272-1283.
APA：

Huo Xiaochuan,Ma Gaoting,Tong Xu,Zhang Xuelei,&ANGEL-ASPECT Investigators.(2023).Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct .NEW ENGLAND JOURNAL OF MEDICINE,388(14):1272-1283.
MLA：

Huo Xiaochuan, et al. "Trial of Endovascular Therapy for Acute Ischemic Stroke with Large Infarct" .NEW ENGLAND JOURNAL OF MEDICINE 388,14(2023):1272-1283.
入库时间：

5/6/2023 9:39:21 AM
更新时间：

5/6/2023 9:39:21 AM
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