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White adipose atrophy exacerbates cold stress and accelerates aging in male mice 期刊论文

编号：

B7ACD7D9E2728656243A431420C88B78
作者：

Liu, Zuojun#^[1,2]Hu, Wenjing^[1,3,4];Tan, Xiaoqing^[1];Sun, Shimin^[1,4];Huang, Xin^[5];Meng, Yuan^[6];Zhao, Nan^[5];Wang, Ming^[6];Wu, Weiwei^[3];Qian, Minxian^[1];Tang, Xiaolong^[1];Pang, Qiuxiang^[3];Wang, Zimei^[5];Su, Wen*^[5]Liu, Baohua*^[1]
语种：

英文
期刊：

NATURE COMMUNICATIONS ISSN：2041-1723 2026 年 17 卷 1 期 ; APR 18
收录：
摘要：

Adipose tissues are highly dynamic in response to environmental temperature changes. During aging, subcutaneous white adipose tissues (WAT) decreases, yet whether this atrophy exacerbates cold stress and triggers systemic aging remains unclear. Here we show that adipocyte-specific expression of the LmnaG609G mutation in male mice leads to progressive WAT atrophy, accelerates aging, and shortens lifespan, whereas female mice remain unaffected. This lipoatrophy exacerbates cold stress, triggering cyclooxygenase-2 (COX-2) upregulation in WAT, and increased prostaglandin E2 production, which mediates the elevation of core body temperature (CBT). Inhibiting COX-2 by celecoxib or thermotherapy by housing the lipoatrophic mice at 26 degrees C (normally 22 degrees C) ameliorates cold stress, restores CBT, reduces aging features, and extends lifespan. Our findings reveal that subcutaneous WAT atrophy and subsequent CBT elevation induced by chronic mild cold stress are drivers of systemic aging in male mice, identifying thermotherapy as a potential regimen for progeria.
推荐引用方式
GB/T 7714：

Liu Zuojun,Hu Wenjing,Tan Xiaoqing, et al. White adipose atrophy exacerbates cold stress and accelerates aging in male mice [J].NATURE COMMUNICATIONS,2026,17(1).
APA：

Liu Zuojun,Hu Wenjing,Tan Xiaoqing,Sun Shimin,&Liu Baohua.(2026).White adipose atrophy exacerbates cold stress and accelerates aging in male mice .NATURE COMMUNICATIONS,17(1).
MLA：

Liu Zuojun, et al. "White adipose atrophy exacerbates cold stress and accelerates aging in male mice" .NATURE COMMUNICATIONS 17,1(2026).
入库时间：

7/12/2026 9:39:45 PM
更新时间：

7/12/2026 9:39:45 PM

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