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Astrocytes orchestrate neuroprotection and pathogenesis via bidirectional neuronal interactions in Parkinson's disease 期刊论文

编号：

BD0A2799CEB5B6B584F83DBE8CB86B49
作者：

Li, Yifan#^[1,2,9]Li, Qiang(李强)#^[1,9]Wang, Yemin^[1,2,9];Wang, Xuejing^[1,2,9];Di, Guangfu(狄广福)^[3,4]Niu, Meng^[5];Xu, Zhiliang(徐志良)*^[6,7,9]Huang, Yanjiao(黄艳姣)*^[1,8,9]
语种：

英文
期刊：

JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY ISSN：1138-7548 2026 年 82 卷 1 期 ; AUG 14
收录：
关键词：

PD Neuroinflammation Astrocytes Signaling pathways Apoptosis
摘要：

Parkinson's disease (PD), a prevalent neurodegenerative disorder, is characterized by the degeneration of dopaminergic neurons in the substantia nigra and striatum of the midbrain, manifesting as distinct motor impairments. While conventional theories attribute PD's development to neuronal damage, astrocytes have garnered significant attention for their potential protective role. As the most abundant glial cells in the central nervous system (CNS), astrocytes may exert neuroprotective effects through mechanisms including secretion of neurotrophic factors, regulation of the blood-brain barrier (BBB), and maintenance of water-electrolyte balance. Recent studies indicate that mutations in PD-associated genes may induce functional alterations in astrocytes. Activated astrocytes accelerate neuronal degeneration by releasing inflammatory mediators, disrupting glutamate homeostasis, and triggering oxidative stress. Furthermore, bidirectional regulatory interactions exist between astrocytes and both dopaminergic neurons and other glial cells in PD. This review systematically summarizes current research on astrocyte involvement in PD pathology and their neuronal interaction mechanisms, further exploring their interconnections to elucidate disease pathogenesis. The findings provide novel theoretical frameworks for developing astrocyte-targeted therapies and preventive strategies against PD.
推荐引用方式
GB/T 7714：

Li Yifan,Li Qiang,Wang Yemin, et al. Astrocytes orchestrate neuroprotection and pathogenesis via bidirectional neuronal interactions in Parkinson's disease [J].JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY,2026,82(1).
APA：

Li Yifan,Li Qiang,Wang Yemin,Wang Xuejing,&Huang Yanjiao.(2026).Astrocytes orchestrate neuroprotection and pathogenesis via bidirectional neuronal interactions in Parkinson's disease .JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY,82(1).
MLA：

Li Yifan, et al. "Astrocytes orchestrate neuroprotection and pathogenesis via bidirectional neuronal interactions in Parkinson's disease" .JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY 82,1(2026).
入库时间：

8/25/2026 9:48:56 PM
更新时间：

8/25/2026 9:48:56 PM

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