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NF- K B Pathway 期刊论文

编号：

D231CBD1E4F05B2A37E803388405D23C
作者：

Tu, Zhenzhen#^[1,2]Wei, Wei^[7];Zeng, Fanjun^[2];Wang, Wenwen^[2];Zhang, Yuyan^[8];Zhang, Yintao^[2];Zhou, Fusheng^[4,5];Cai, Chunlin^[3];Zhang, Siping*^[7]Zhou, Haisheng*^[2,5,6,9]
语种：

英文
期刊：

AMERICAN JOURNAL OF PATHOLOGY ISSN：0002-9440 2024 年 194 卷 5 期 (708 - 720) ; MAY
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摘要：

Psoriasis is a chronic in fl ammatory skin disease characterized by the activation of keratinocytes and the in fi ltration of immune cells. Overexpression of the transcription factor LIM-domain only protein 4 (LMO4) promoted by IL-23 has critical roles in regulating the proliferation and differentiation of psoriatic keratinocytes. IL-6, an autocrine cytokine in psoriatic epidermis, is a key mediator of IL-23/T helper 17-driven cutaneous in fl ammation. However, little is known about how IL-6 regulates the upregulation of LMO4 expression in psoriatic lesions. In this study, human immortalized keratinocyte cells, clinical biopsy specimens, and an animal model of psoriasis induced by imiquimod cream were used to investigate the role of IL-6 in the regulation of keratinocyte proliferation and differentiation. Psoriatic epidermis showed abnormal expression of IL-6 and LMO4. IL-6 up-regulated the expression of LMO4 and promoted keratinocyte proliferation and differentiation. Furthermore, in vitro and in vivo studies showed that IL-6 up-regulates LMO4 expression by activating the mitogen-activated extracellular signal-regulated kinase (MEK)/extracellular signal-regulated kinase (ERK)/NF- k B signaling pathway. These results suggest that IL-6 can activate the NF- k B signaling pathway, up-regulate the expression of LMO4, lead to abnormal proliferation and differentiation of keratinocytes, and promote the occurrence and development of psoriasis. (Am J Pathol 2024, 194: 708 - 720; https://doi.org/ 10.1016/j.ajpath.2024.01.014)
推荐引用方式
GB/T 7714：

Tu Zhenzhen,Wei Wei,Zeng Fanjun, et al. IL-6 Up-Regulates Expression of LIM-Domain Only Protein 4 in Psoriatic Keratinocytes through Activation of the MEK/ERK/NF- K B Pathway [J].AMERICAN JOURNAL OF PATHOLOGY,2024,194(5):708-720.
APA：

Tu Zhenzhen,Wei Wei,Zeng Fanjun,Wang Wenwen,&Zhou Haisheng.(2024).IL-6 Up-Regulates Expression of LIM-Domain Only Protein 4 in Psoriatic Keratinocytes through Activation of the MEK/ERK/NF- K B Pathway .AMERICAN JOURNAL OF PATHOLOGY,194(5):708-720.
MLA：

Tu Zhenzhen, et al. "IL-6 Up-Regulates Expression of LIM-Domain Only Protein 4 in Psoriatic Keratinocytes through Activation of the MEK/ERK/NF- K B Pathway" .AMERICAN JOURNAL OF PATHOLOGY 194,5(2024):708-720.
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